Gratitude, excitement surround Graduate Commons Program leadership transition

first_imgThe Graduate Commons Program (GCP) will soon bid farewell to faculty directors Jim and Doreen Hogle, after seven years of service and mentorship to the Peabody Terrace community. They will retire to Vermont following a year of research at the University of Leeds (U.K.) where Jim Hogle — currently the Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology and director of the Hogle Lab — will be a visiting professor. Residents said they will miss their exceptional leadership, kind natures, and generosity of spirit.The couple are warm and inviting hosts whose monthly open houses and other events enabled residents of all ages and affiliations to find a support system within Harvard University Housing. They’ve hosted dozens of engaging speakers as part of their commitment to “learning outside of the classroom,” reinforcing GCP’s goal to build bridges between disciplines and cultures. Special guests included George Church of Project Genome and Harvard Medical School, Pulitzer-prize winning historian Annette Gordon-Reed, and visiting gender and identity scholar Keridwen Luis.When asked about their participation in the program, Jim and Doreen shared, “It has been a pleasure to work with the wonderful GCP staff and community advisors over the years, and a privilege to be part of the remarkably talented and engaging Peabody Terrace community of students and their families. It has truly enriched our lives, and we have learned so much from sharing with this group.”As the Hogles take this next step, Graduate Commons is excited to welcome new faculty directors, Vinny Manoharan, Michelle Carter, and their son, Samuel, to the Peabody Terrace community this August. Vinny is the Wagner Family Professor of Chemical Engineering and Professor of Physics, and the co-director of the Quantitative Biology Initiative at Harvard’s John A. Paulson School of Engineering and Applied Sciences and the Faculty of Arts and Sciences.“The Harvard experience isn’t just about academics, but also about being part of an amazing community,” said Vinny. “Unfortunately, as I learned through my work on the SEAS Committee on Diversity, Inclusion, and Belonging, not everyone feels that sense of belonging. The Graduate Commons Program goes a long way towards addressing that issue, and we’re eager to be part of it.”Michelle, a practicing painter, is assistant professor and chair of the Art and Design Program at Northern Essex Community College, where she teaches drawing, painting, and design foundations. Fostering community is key to Michelle’s work at NECC, which has many non-traditional students with significant responsibilities outside of school. “My colleagues and I create a supportive environment by getting to know all our students, organizing exciting events, and emphasizing strong communication.” said Michelle. “I’m looking forward to doing similar work with the Peabody Terrace community.“We’re grateful to the Hogles for cultivating such a welcoming community. We were drawn to this position because it’s a unique opportunity to live among and make connections between people from very different disciplines and backgrounds. We’re excited to get to know the residents!”last_img read more

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In liver, a stressed cell can be bad news for its neighbors

first_img Read Full Story A key protein in the communication channels between cells can allow a stress response in one liver cell to spread to neighboring liver cells in mice, causing otherwise healthy cells to become dysfunctional, according to new research co-led by Harvard T.H. Chan School of Public Health and Sheba Medical Center in Israel. The findings could have implications for a range of metabolic diseases, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD).The study is the first to demonstrate that the protein, Cx43, plays a role in the spread of endoplasmic reticulum (ER) stress signals among liver cells. Remarkably, the researchers noted, mice lacking Cx43 in their livers were protected from insulin resistance, glucose intolerance, and NAFLD.The findings were published in Cell Metabolism on Dec. 18, 2020.“We found that when a stressed liver cell starts communicating with its neighbors, it can send stress signals to neighboring cells, causing significant problems that can lead to fatty liver disease and metabolic disease,” said corresponding author Gökhan Hotamışlıgil, James Stevens Simmons Professor of Genetics and Metabolism at Harvard Chan School and director of the Sabri Ülker Center for Metabolic Research. “Here, we developed complex methods to follow molecular stress signals as they pass from one cell to another and, importantly, we showed that when these signals are stopped in the originating cell, metabolic health can be preserved even under adverse conditions such as obesity.”Previous research in the Sabri Ülker Center has shown that in obese animals and humans, liver tissue experiences stress and dysfunction of the ER. It has, however, been challenging to understand why this powerful tissue failed to launch countermeasures to mitigate this problem. The researchers found in this study that once a small group of cells in the liver experience stress, it quickly spreads to the rest of the tissue, from cell to cell, overwhelming the tissue’s natural defenses.For this new study, the researchers first screened billions of cells to find a few that naturally exhibit ER stress and others that have no sign of stress whatsoever. When they were grown next to each other, the stressed cells passed stress signals on to the healthy cells. The team then focused on liver cells isolated from mice. They experimentally induced ER stress in these cells and observed that levels and activity of Cx43 increased. As Cx43 activity increased, these cells became more capable of transmitting stress signals to nearby cells when compared with cells that were not under ER stress.To build on these initial findings, the research team conducted a series of experiments on mice and determined that diet-induced obesity resulted in ER stress that in turn increased levels and activity of Cx43. The team then created a line of mice in which Cx43 had been deleted from the animals’ liver cells. In these mice, a high-fat diet did not trigger ER stress in liver cells, and the animals were protected from insulin resistance, glucose intolerance, and NAFLD.last_img read more

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Room yields dead man

first_imgPolice identified him as HerbertSevilla, a resident of the village. Herbert’s lifeless body was discovered byhis brother Hobby around 8:10 a.m. on Wednesday.   ILOILO City – A 61-year-old man was found dead inside his room in Barangay Liberation, City Proper.center_img Responding police officers did not findany wounds on Herbert’s body suggestive of murder.It was however not immediately clear if foul play was ruled out in his death./PNlast_img

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Battle for the Green Jacket starts today

first_imgPhoto © – Tipp FM Dustin Johnson remains a doubt for the Masters which starts tonight.The favourite had a fall at home and is suffering with a back injury.Johnson’s due in the last group out, playing with two-time Masters champion Bubba Watson and Jimmy Walker. Shane Lowry plays alongside Sergio Garcia and Lee Westwood from just before 6.20, Irish time.Rory McIlroy is also among the late starters, grouped with big-hitting Spaniard Jon Rahm and Japan’s Hideto Tanihara.The green jacket is the only Major prize to have eluded McIlroy so far.last_img

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Division threatens Premier League’s chances of comeback

first_imgLondon, United Kingdom | AFP | Warring Premier League clubs will meet on Monday with tensions mounting over the divisive ‘Project Restart’ plan to finish the season amid the coronavirus crisis.Premier League chiefs hope to return to action in June, but that goal could be scuppered by an internal battle between clubs fiercely protecting their own interests.The Premier League delayed their latest meeting until after British Prime Minister Boris Johnson’s address to the nation on Sunday.But, for those clubs and players concerned about the rush to return, Johnson’s admission that the virus transmission rate is still too high to significantly ease Britain’s lockdown until at least June 1 was hardly reassuring.Johnson offered no details about the Premier League’s short-term future and indicated that while the general population will be allowed to play sports from Wednesday, they must do so only with those in their own households.And the growing unease about the Premier League’s desire to finish their remaining 92 fixtures only increased on Sunday when Brighton admitted a third player in their squad had contracted the virus.The scheduled return of Germany’s Bundesliga from May 16 had raised hopes that the Premier League could follow suit, yet there are stark differences between the health crisis in both countries.Britain’s death toll from the pandemic passed 30,000 this week to become the worst hit country in Europe.By contrast, Germany has registered just over 7,000 deaths.However, German second tier club Dynamo Dresden have put their entire squad and coaching staff into two-week isolation after two players tested positive for the virus.Also on Sunday, La Liga confirmed five unnamed players have the virus and will go into quarantine.Brighton chief executive Paul Barber has been one of the more vocal critics of the restart scheme and he told the Mail on Sunday: “We have got to be careful that we do not misstep here because if we do, it could ruin lives. It could cost lives. And we cannot afford that.”Testing and player welfare remain major hurdles to overcome, with Norwich midfielder Todd Cantwell summing up the feelings of worried players when he responded to the positive test at Brighton by tweeting: “We are just people too”.– ‘Huge challenge’ – A lack of unity has provoked another complication for the Premier League over the use of neutral venues.League chiefs believe they will only get the government’s green light to restart if the number of venues are limited to reduce the medical, police, security and broadcast personnel required.There are also fears over fans congregating at home stadiums, even though the matches would be played behind closed doors.Leading the resistence to neutral venues are clubs near the bottom of the table and at risk of huge financial losses by dropping out of England’s lucrative top-flight.Brighton had five of their remaining nine games at home, while Aston Villa were due to play six of their last 10 matches at Villa Park.“What we can’t accept is a fundamental change to the competition three-quarters of the way through,” Barber said.“That is not fair and there is absolutely nobody who will convince me otherwise.”Villa’s chief executive Christian Purslow said giving up home advantage “is a massive decision”.Seven of the 20 top-flight clubs would need to officially reject neutral venues to stop the plan going ahead, although it has been reported the issue won’t be put to a vote on Monday.The UEFA deadline for restart proposals is May 25 and League Managers Association chief executive Richard Bevan has warned a failure to reach consensus soon could see the season cancelled.Aware of the animosity between clubs, Crystal Palace chairman Steve Parish conceded it won’t be easy to restart in the current climate.“It may prove beyond us. We have huge challenges in order to get it back to complete the season but we are planning on doing so,” Parish told the BBC.“There are no easy answers. We have to work through it as a collective. I think we will come out with a consensus in the end.”Share on: WhatsApplast_img read more

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Steelers sign free agent RB LeGarette Blount

first_imgLeGarette Blount (AP Photo/File)PITTSBURGH (AP) – The Pittsburgh Steelers and free agent running back LeGarette Blount have agreed on a two-year contract that will give the team needed depth in the backfield behind budding star Le’Veon Bell.The 27-year-old Blount ran for 772 yards and a career-high seven touchdowns in 2013 for the New England Patriots. He added 166 yards rushing and set a team playoff record with four touchdowns in a playoff win over the Indianapolis Colts.The Steelers need bodies in the backfield after Jonathan Dwyer and Felix Jones were not re-signed after last season. Blount has 2,711 yards rushing and 20 touchdowns in 56 games, with 28 career starts.The 6-foot, 250-pound Blount also gives the Steelers a big back near the goal line to complement the 6-2, 230-pound Bell.last_img read more

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Road to Success: Virat Kohli reveals the course of action for the 2020 T20…

first_imgImage Courtesy: Cricket World CupAdvertisement 3e438NBA Finals | Brooklyn Vs6t3wxxWingsuit rodeo📽Sindre E3mq( IG: @_aubreyfisher @imraino ) 2cdWould you ever consider trying this?😱jx4Can your students do this? 🌚w0oRoller skating! Powered by Firework The Men In Blue have managed to qualify for the semi-final of every major ICC tournament since the 2013 Champions Trophy but have failed to win. Virat Kohli aims to be the second captain after MS Dhoni to lift the T20 World Cup.Advertisement Image Courtesy: Cricket World CupThe Indian skipper claims that the management aims to find the balanced squad for the showpiece event that will take place in Australia next year. He also added that the players would be motivated to grab the spots. He said:“The T20 World Cup in 2020 is a big focus for us, and it’s important that we use the next 12 months to place ourselves in the best possible position to compete for another major ICC trophy,” Advertisement “Our players will be really motivated to take their opportunities when they get selected for T20I matches to put themselves forward for the T20 World Cup, as we want to have a settled team combination by the time we get to Australia,” Kohli recalled India’s triumph in the very first T20 World Cup in South Africa and added that it would be an honor to be the second Indian captain to lift the trophy for the country. The skipper added that he looks forward to the crowd support as they had turned up in numbers during the 2015 World Cup. He stated:Advertisement “India won the inaugural T20 World Cup in 2007 when the format was new and the future a bit unknown. Since then, T20 cricket has truly come of age and it would be an honor to be the second Indian captain to lift the T20 World Cup trophy, and hopefully the third if the Indian women can win it earlier in 2020,” Kohli said.“We receive such incredible support when we play in Australia, with stadiums often packed with a sea of blue shirts. I hope to see more of that when we come back to Australia next year,”Read Also:Sachin Tendulkar backs Sourav Ganguly to deliver as BCCI bossFit of fury: Aiden Markram’s tour comes to an end after self inflicted wrist injury  Advertisementlast_img read more

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